[HTML][HTML] DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

GSDME and its role in cancer: From behind the scenes to the front of the stage

E De Schutter, L Croes, J Ibrahim… - … Journal of Cancer, 2021 - Wiley Online Library
Gasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been
associated with several types of cancer in the last two decades. Recently, GSDME was …

Clinical significance of novel DNA methylation biomarkers for renal clear cell carcinoma

R Kubiliūtė, K Žukauskaitė, A Žalimas, A Ulys… - Journal of Cancer …, 2022 - Springer
Objective Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor
characterized by the highest mortality rate of the genitourinary cancers, and, therefore, new …

Use of DNA methylation profiling in translational oncology

V Ortiz-Barahona, RS Joshi, M Esteller - Seminars in cancer biology, 2022 - Elsevier
DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Non‐invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study

Y Xiao, L Ju, K Qian, W Jin, G Wang… - Clinical and …, 2022 - Wiley Online Library
Background State‐of‐art non‐invasive diagnosis processes for bladder cancer (BLCA)
harbour shortcomings such as low sensitivity and specificity, unable to distinguish between …

[HTML][HTML] DNA methylation as a therapeutic target for bladder cancer

SP Nunes, R Henrique, C Jerónimo, JM Paramio - Cells, 2020 - mdpi.com
Bladder cancer (BC) is the tenth most frequent cancer worldwide and is associated with high
mortality when diagnosed in its most aggressive form, which is not reverted by the current …

[HTML][HTML] Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation

AE Hentschel, IJ Beijert, J Bosschieter, PC Kauer… - Clinical …, 2022 - Springer
Background The development of accurate urinary biomarkers for non-invasive and cost-
effective detection of primary and recurrent bladder tumours is recognized as one of the …

[HTML][HTML] Epigenetic biomarkers of renal cell carcinoma for liquid biopsy tests

R Kubiliute, S Jarmalaite - International journal of molecular sciences, 2021 - mdpi.com
Renal cell carcinomas (RCC) account for 2–3% of the global cancer burden and are
characterized by the highest mortality rate among all genitourinary cancers. However …

Multi-omics identification of an immunogenic cell death-related signature for clear cell renal cell carcinoma in the context of 3P medicine and based on a 101 …

J Liu, Y Shi, Y Zhang - EPMA Journal, 2023 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is a prevalent urological malignancy
associated with a high mortality rate. The lack of a reliable prognostic biomarker undermines …

[HTML][HTML] Non-invasive detection of endometrial cancer by DNA methylation analysis in urine

R van den Helder, BMM Wever, NE van Trommel… - Clinical …, 2020 - Springer
Background The incidence of endometrial cancer is rising, and current diagnostics often
require invasive biopsy procedures. Urine may offer an alternative sample type, which is …