The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Bronchiectasis is a complex and heterogeneous inflammatory chronic respiratory disease
with an unknown cause in around 30–40% of patients. The presence of airway infection …

Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic
subtypes have recently been described. Objectives: To use multiple datasets available …

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease
(COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression …

Studies have shown that gut microbiota metabolites can enter the central nervous system via
the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary …

Although previous studies have reported the dysregulation of respiratory tract microbiota in
infectious diseases, insufficient data exist regarding respiratory microbiota imbalances in the …

Rationale: Although inflammation and infection are key disease drivers in bronchiectasis,
few studies have integrated host inflammatory and microbiome data to guide precision …

Bronchiectasis is a common progressive respiratory disease with recognisable radiological
abnormalities and a clinical syndrome of cough, sputum production and recurrent respiratory …

Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant
morbidity, underpinned by a complex interplay between microbial dysbiosis and immune …

Bronchiectasis is a major health problem that is increasing in prevalence and burden
globally [1, 2]. The impact of bronchiectasis on patients and the healthcare system is …