The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

Ceftazidime-avibactam (Zavicefta®) is an intravenously administered combination of the
third-generation cephalosporin ceftazidime and the novel, non-β-lactam β-lactamase …

Bloodstream infection (BSI) organisms were consecutively collected from> 200 medical
centers in 45 nations between 1997 and 2016. Species identification and susceptibility …

Summary Background Carbapenem-resistant Gram-negative bacteria represent the highest
priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new …

SUMMARY A balanced gut microbiota contributes to health, but the mechanisms
maintaining homeostasis remain elusive. Microbiota assembly during infancy is governed by …

ABSTRACT Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …

Background Carbapenems are frequently the last line of defence in serious infections due to
multidrug-resistant Gram-negative bacteria, but their use is threatened by the growing …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) are the most common
types of infections in women. The antibiotic resistance of E. coli is increasing rapidly …

The management of infections due to Klebsiella pneumoniae has been complicated by the
emergence of antimicrobial resistance, especially to carbapenems. Resistance to …