Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Recapitulating macro-scale tissue self-organization through organoid bioprinting
Bioprinting promises enormous control over the spatial deposition of cells in three
dimensions,,,,,–, but current approaches have had limited success at reproducing the …
dimensions,,,,,–, but current approaches have had limited success at reproducing the …
Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …
development, regeneration, and disease in vitro. However, the control of engineered …
Volumetric bioprinting of complex living‐tissue constructs within seconds
Biofabrication technologies, including stereolithography and extrusion‐based printing, are
revolutionizing the creation of complex engineered tissues. The current paradigm in …
revolutionizing the creation of complex engineered tissues. The current paradigm in …
[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …
attention as a way to better mimic the complex interactions between individual cells and the …
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
CR Below, J Kelly, A Brown, JD Humphries, C Hutton… - Nature materials, 2022 - nature.com
Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …
tumours are essential for basic and translational cancer biology. Here, we describe a fully …
3D extrusion bioprinting
YS Zhang, G Haghiashtiani, T Hübscher… - Nature Reviews …, 2021 - nature.com
Abstract Three-dimensional (3D) bioprinting strategies use computer-aided processes to
enable automated simultaneous spatial patterning of cells and/or biomaterials. These …
enable automated simultaneous spatial patterning of cells and/or biomaterials. These …
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues
The generation of organoids and tissues with programmable cellular complexity,
architecture and function would benefit from the simultaneous differentiation of human …
architecture and function would benefit from the simultaneous differentiation of human …
The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics
A Elosegui-Artola - Current opinion in cell biology, 2021 - Elsevier
The extracellular matrix mechanical properties regulate processes in development, cancer,
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …