Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …

The bacterial phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS)
carries out both catalytic and regulatory functions. It catalyzes the transport and …

The past two decades have seen a worldwide resurgence in infections caused by
Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity …

To construct a superior microbial cell factory for chemical synthesis, a major challenge is to
fully exploit cellular potential by identifying and engineering beneficial gene targets in …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

Metabolically versatile free-living bacteria have global regulation systems that allow cells to
selectively assimilate a preferred compound among a mixture of several potential carbon …

Glucose arguably is the most important energy carrier, carbon source for metabolites and
building block for biopolymers in all kingdoms of life. The proper function of animal organs …

Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

Like for all microbes, the goal of every pathogen is to survive and replicate. However, to
overcome the formidable defenses of their hosts, pathogens are also endowed with traits …