Identifying patients who are at high risk for severe Clostridium difficile–associated disease
(CDAD) early in the course of their infection may help clinicians improve outcomes …

Clostridioides difficile is the most common cause of healthcare-associated diarrhea. Disease
complications as well as recurrent infections contribute significantly to morbidity and …

Clostridium difficile colitis has doubled in North America over the past 5 years and recent
reports have demonstrated an increase in incidence and severity of these infections in …

The increase of pro-inflammatory cytokines and oxidative stress leads to β-cell damage and
promotes β-cells apoptosis, in types I and II of diabetes mellitus. Therefore, blocking of pro …

Objectives Multidrug resistance and antibiotic resistance mechanisms were investigated in
316 Clostridium difficile clinical isolates collected during the first European surveillance on …

Background. Previous studies of risk factors for Clostridium difficile—associated disease
(CDAD) have been limited by small sample sizes and case-control study designs. Many of …

Recurrent Clostridium difficile infection (CDI) occurs in up to 35% of patients. Recurrences
can be due to either relapse with the same strain or reinfection with another strain. In this …

Managing serious infections is a balance between providing timely and appropriate broad-
spectrum empirical therapy for individual patients, which has been consistently shown to …

Background. Clostridium difficile colitis has increased in incidence and severity, and
treatment failure with metronidazole therapy has increasingly been documented. It is …

Background Clostridium difficile is the most common cause of nosocomial infectious
diarrhea in the United States. However, recent reports have documented that C. difficile …