DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Cancer is the quintessential complex disease. As technologies evolve faster each day, we
are able to quantify the different layers of biological elements that contribute to the …

Predicting the prognosis of pancreatic cancer is important because of the very low survival
rates of patients with this particular cancer. Although several studies have used microRNA …

Innovative multi-omics frameworks integrate diverse datasets from the same patients to
enhance our understanding of the molecular and clinical aspects of cancers. Advanced …

Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide.
Although there is a heritable component, the etiology of AUD is complex and can involve …

Rationale: Although sunitinib has been shown to improve the survival rate of advanced renal
cell carcinoma (RCC) patients, poor drug response is a major challenge that reduces patient …

Epigenetics refers to nucleotide sequence-independent events, and heritable changes,
including DNA methylation and histone modification (as the two main processes) …

Cell-free DNA (cfDNA) methylation profiling is considered promising and potentially reliable
for liquid biopsy to study progress of diseases and develop reliable and consistent …

Background Colorectal cancer is the fourth cause of cancer-related deaths worldwide,
though detection at early stages associates with good prognosis. Thus, there is a clear …

Background The combination of sodium bisulfite treatment with highly-parallel sequencing is
a common method for quantifying DNA methylation across the genome. The power to detect …