Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

Objectives To describe the achievement of unbound β-lactam antibiotic concentration
targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the …

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …

Background Precision dosing programs are promising tools for optimising antimicrobial
dosing. Selecting the ideal program for local application may be challenging due to the large …

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-
based antibiotic dosing software aids in achieving concentration targets in critically ill …

Despite therapeutic advances over recent decades, the mortality rate for sepsis and septic
shock is still approximately 25% worldwide. Early administration of appropriate intravenous …

Background Beta-lactam antimicrobial concentrations are frequently suboptimal in critically
ill patients. Population pharmacokinetic (PopPK) modeling is the golden standard to predict …

Fosfomycin combined with other antimicrobials has shown good efficacy against multidrug-
resistant (MDR) bacteria in both in vitro and clinical studies; however, the activity of …

ABSTRACT KPC-producing Klebsiella pneumoniae causes serious infections associated
with high death rates worldwide. Combination therapy consisting of fosfomycin and a …