Frontotemporal dementia (FTD) refers to a group of clinically and genetically heterogeneous
neurodegenerative disorders that are a common cause of adult-onset behavioural and …

Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective
elimination of dysfunctional mitochondria. To this date, parkin depletion has been …

Introduction Progranulin (PGRN) is a secreted glycoprotein, the expression of which is
linked to several neurodegenerative diseases. Although its specific function is still unclear …

Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-
dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar …

Stroke is primarily a neurodegenerative disease but can also severely impact the functions
of other vital organs and deteriorate disease outcomes. A malfunction of the gastrointestinal …

Abstract Background Neurotransmitters deficits in Frontotemporal Dementia (FTD) are still
poorly understood. Better knowledge of neurotransmitters impairment, especially in …

Frontotemporal dementia is a clinically and pathologically heterogeneous group of
neurodegenerative disorders, with progressive impairment of behavior and language. They …

Introduction A phenotype of isolated parkinsonism mimicking Idiopathic Parkinson's Disease
(IPD) is a rare clinical presentation of GRN and C9orf72 mutations, the major genetic causes …

Familial frontotemporal lobar degeneration (FTLD) is a pathologically heterogeneous group
of neurodegenerative diseases with diverse genotypes and clinical phenotypes. Three …

Blood levels of progranulin (PGRN) are suggested to be decreased in patients with
Parkinson's disease (PD). However, the association between blood levels of progranulin …