Advances in targeting central sensitization and brain plasticity in chronic pain

AH Bazzari, FH Bazzari - The Egyptian Journal of Neurology, Psychiatry …, 2022 - Springer
Maladaptation in sensory neural plasticity of nociceptive pathways is associated with various
types of chronic pain through central sensitization and remodeling of brain connectivity …

Predicting pain after standard pain therapy for knee osteoarthritis–the first steps towards personalized mechanistic-based pain medicine in osteoarthritis

KKS Petersen - Scandinavian Journal of Pain, 2023 - degruyter.com
Objectives The prevalence of osteoarthritis (OA) is rising, and pain is the hallmark symptom
of OA. Pain in OA is complicated and can be influenced by multiple joint-related factors and …

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute …

ML Plinsinga, V Vuvan, L Maclachlan, D Klyne… - Pain, 2023 - journals.lww.com
Reduced conditioned pain modulation (CPM) and psychological distress co-occur frequently
in many pain conditions. This study explored whether common negative pain cognitions and …

The modulatory effect of quantitative sensory testing in shoulder pain: a systematic review and meta-analysis

KD Lyng, JBB Thorsen, DB Larsen… - Pain Medicine, 2022 - academic.oup.com
Background The underlying mechanisms for shoulder pain (SP) are still widely unknown.
Previous reviews have reported signs of altered pain processing in SP measured with …

The influence of exercise on clinical pain and pain mechanisms in patients with subacromial pain syndrome

KD Lyng, JD Andersen, SL Jensen… - … Journal of Pain, 2022 - Wiley Online Library
Background Few studies have investigated the underlying mechanisms for unilateral
subacromial pain syndrome (SAPS). Therefore, this study examined (1) if 8‐weeks of …

The association between conditioned pain modulation and psychological factors in people with chronic spinal pain: A systematic review

M Mansfield, G Roviello, M Thacker… - British Journal of …, 2024 - journals.sagepub.com
Chronic spinal pain has negative effects on physical and mental well-being. Psychological
factors can influence pain tolerance. However, whether these factors influence descending …

[HTML][HTML] Lifestyle factors and psychological factors are associated with central pain processing in service members with persistent low-back pain: A cross-sectional …

JM Prent, P van der Wurff, GGM Scholten-Peeters - Medicine, 2023 - journals.lww.com
Persistent low-back pain (LBP) is highly prevalent in the military. Altered central pain
processing is one of the mechanisms found to underlie persistent LBP. Our aim was to …

Pain catastrophizing: A patient-centered approach to assessment

OJ Thompson, K Powell-Roach, JL Taylor, EL Terry… - …, 2022 - journals.lww.com
Pain is a subjective experience and its perception and expression vary widely. Pain
catastrophizing, which refers to patients' thoughts or feelings about their pain, may impact …

Intrinsic brain connectivity alterations despite intact pain inhibition in subjects with neuropathic pain after spinal cord injury: a pilot study

V Huynh, R Lütolf, J Rosner, R Luechinger, A Curt… - Scientific Reports, 2023 - nature.com
Endogenous pain modulation in humans is frequently investigated with conditioned pain
modulation (CPM). Deficient pain inhibition is a proposed mechanism that contributes to …

Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial

C Gevers-Montoro, A Ortega-De Mues, M Piché - BMJ open, 2023 - bmjopen.bmj.com
Introduction Chronic low back pain (CLBP) is a highly prevalent and disabling condition.
Identifying subgroups of patients afflicted with CLBP is a current research priority, for which a …