Peptide nucleic acid (PNA) is a DNA analog, in which the sugar-phosphate backbone in
DNA is replaced by poly [N-(2-aminoethyl) glycine]. Since its discovery in the early 1990s …

Over the last three decades, our view of RNA has changed from a simple intermediate
supporting protein synthesis to a major regulator of biological processes. In the expanding …

We have developed a new class of triplex-forming peptide nucleic acid (PNA)-based
fluorogenic probes for sensing of the panhandle structure of the influenza A virus (IAV) RNA …

In order to overcome the pH limitations of triplex-forming peptide nucleic acid (PNA) in
binding to double-stranded RNA (dsRNA), we have recently proposed a new design of …

In contrast to well-established DNA-selective dyes for live cell imaging, RNA-selective dyes
have been less developed owing to the challenges of making small molecules have RNA …

Small-molecules interacting with particular RNAs and modulating their functions are vital
tools for RNA-targeting drug discovery. Considering the substantial distribution of the …

Fluorescence indicators capable of binding to human immunodeficiency virus-1 (HIV-1)
trans-activation responsive (TAR) RNA are powerful tools for the exploratory studies of the …

Ovarian cancer (OC) is one of the most lethal gynecologic cancers that is typically
diagnosed at the very late stage of disease progression. Thus, there is an unmet need to …

Here we report on fine-tuning of highly bright fluorogenic cyanine dye, benzo [c, d] indole-
oxazolo [5, 4-c] pyridine (BIOP: λ em= 570 nm, Φ free= 0.00038, Φ bound= 0.52), recently …

Unlike conventional triplex‐forming oligonucleotide (TFO), triplex‐forming peptide nucleic
acid (PNA) can tightly bind with double‐stranded RNA (dsRNA) than double‐stranded DNA …