[HTML][HTML] Interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease

Y Chen, W Cui, X Li, H Yang - Frontiers in Immunology, 2021 - frontiersin.org
In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are
severely damaged, and then their susceptibility to bacteria increases, so many commensal …

The multifaceted virulence of adherent-invasive Escherichia coli

S Mansour, T Asrar, W Elhenawy - Gut Microbes, 2023 - Taylor & Francis
The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the
role of the gut microbiome in CD development is unresolved, the frequent isolation of …

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

CR Shaler, AA Parco, W Elhenawy, J Dourka… - Nature …, 2021 - nature.com
Crohn's disease is an inflammatory disease of the gastrointestinal tract characterized by an
aberrant response to microbial and environmental triggers. This includes an altered …

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli

W Elhenawy, S Hordienko, S Gould, AM Oberc… - Nature …, 2021 - nature.com
Adherent-invasive Escherichia coli (AIEC) are pathogenic bacteria frequently isolated from
patients who have Crohn's disease (CD). Despite the phenotypic differences between AIEC …

Safety and efficacy of an AIEC-targeted bacteriophage cocktail in a mice colitis model

M Titécat, C Rousseaux, C Dubuquoy… - Journal of Crohn's …, 2022 - academic.oup.com
Background and aims Adherent invasive Escherichia coli [AIEC] are recovered with a high
frequency from the gut mucosa of Crohn's disease patients and are believed to contribute to …

[HTML][HTML] Role of adherent invasive Escherichia coli in pathogenesis of inflammatory bowel disease

L Zheng, SL Duan, YC Dai, SC Wu - World journal of clinical cases, 2022 - ncbi.nlm.nih.gov
Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but
no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum …

Siderophore immunization restricted colonization of adherent-invasive Escherichia coli and ameliorated experimental colitis

RR Gerner, S Hossain, A Sargun, K Siada, GJ Norton… - MBio, 2022 - Am Soc Microbiol
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
gastrointestinal tract and profound alterations to the gut microbiome. Adherent-invasive …

Effect of β-Glucan Supplementation on Growth Performance and Intestinal Epithelium Functions in Weaned Pigs Challenged by Enterotoxigenic Escherichia coli

Y Zhou, Y Luo, B Yu, P Zheng, J Yu, Z Huang, X Mao… - Antibiotics, 2022 - mdpi.com
Background: To examine the effect of β-glucan (BGL) supplementation on growth
performance and intestinal epithelium functions in weaned pigs upon Enterotoxigenic …

The unique lifestyle of Crohn's disease-associated adherent-invasive Escherichia coli

CR Shaler, W Elhenawy, BK Coombes - Journal of molecular biology, 2019 - Elsevier
Escherichia coli is one of the most genetically and phenotypically diverse species of
bacteria. This remarkable diversity produces a plethora of clinical outcomes following …

Genetic and Phenotypic Features to Screen for Putative Adherent-Invasive Escherichia coli

C Camprubí-Font, C Ewers, M Lopez-Siles… - Frontiers in …, 2019 - frontiersin.org
To date no molecular tools are available to identify the adherent-invasive Escherichia coli
(AIEC) pathotype, which has been associated with Crohn's disease and colonizes the …