Pyoderma gangrenosum

E Maverakis, AV Marzano, ST Le, JP Callen… - Nature Reviews …, 2020 - nature.com
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly
developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema …

Curcumin: an inflammasome silencer

S Hasanzadeh, MI Read, AR Bland, M Majeed… - Pharmacological …, 2020 - Elsevier
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …

The role of tumor inflammatory microenvironment in lung cancer

Z Tan, H Xue, Y Sun, C Zhang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the most common and fatal malignant tumor in the world. The tumor
microenvironment (TME) is closely related to the occurrence and development of lung …

TNF in the liver: targeting a central player in inflammation

G Tiegs, AK Horst - Seminars in immunopathology, 2022 - Springer
Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

Tumour necrosis factor alpha in intestinal homeostasis and gut related diseases

B Ruder, R Atreya, C Becker - International journal of molecular sciences, 2019 - mdpi.com
The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Personalizing treatment in IBD: hype or reality in 2020? Can we predict response to anti-TNF?

R Atreya, MF Neurath, B Siegmund - Frontiers in medicine, 2020 - frontiersin.org
The advent of anti-TNF agents as the first approved targeted therapy in the treatment of
inflammatory bowel disease (IBD) patients has made a major impact on our existing …

Etiology of IBD—is it still a mystery?

A Kofla-Dłubacz, T Pytrus, K Akutko… - International journal of …, 2022 - mdpi.com
Inflammatory bowel diseases (IBD), including colitis ulcerosa and Crohn's disease, are
chronic diseases of the gastrointestinal tract for which the cause has not been fully …

Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production

Z Gong, S Zhao, J Zhou, J Yan, L Wang, X Du, H Li… - Molecular …, 2018 - Elsevier
Background NLRP3 inflammasome mediates IL-1β maturation, therefore plays a vital role in
the development of IBD. Curcumin is known for possessing strong anti-inflammatory …

Tumor-stroma-inflammation networks promote pro-metastatic chemokines and aggressiveness characteristics in triple-negative breast cancer

Y Liubomirski, S Lerrer, T Meshel… - Frontiers in …, 2019 - frontiersin.org
The tumor microenvironment (TME) plays key roles in promoting disease progression in the
aggressive triple-negative subtype of breast cancer (TNBC; Basal/Basal-like). Here, we took …

Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review

D Tateiwa, H Yoshikawa, T Kaito - Cells, 2019 - mdpi.com
Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …