Interplay between cellular and molecular mechanisms underlying inflammatory bowel diseases development—a focus on ulcerative colitis
Inflammatory bowel diseases (IBD) are defined by the continuous inflammation of the
gastrointestinal tract. During inflammation, the number of pathogens in the intestinal …
gastrointestinal tract. During inflammation, the number of pathogens in the intestinal …
[HTML][HTML] Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease
L Chapuy, M Bsat, S Sarkizova, M Rubio, A Therrien… - Mucosal …, 2019 - Elsevier
Inflammatory bowel diseases are associated with dysregulated immune responses in the
intestinal tissue. Four molecularly identified macrophage subsets control immune …
intestinal tissue. Four molecularly identified macrophage subsets control immune …
Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases
S Nikolaus, GH Waetzig, S Butzin, M Ziolkiewicz… - International journal of …, 2018 - Springer
Abstract Purpose Interleukin-6 (IL-6) production and signalling are increased in the inflamed
mucosa in inflammatory bowel diseases (IBD). As published serum levels of IL-6 and its …
mucosa in inflammatory bowel diseases (IBD). As published serum levels of IL-6 and its …
Preclinical development of a novel, orally-administered anti-tumour necrosis factor domain antibody for the treatment of inflammatory bowel disease
JS Crowe, KJ Roberts, TM Carlton, L Maggiore… - Scientific reports, 2018 - nature.com
TNFα is an important cytokine in inflammatory bowel disease. V565 is a novel anti-TNFα
domain antibody developed for oral administration in IBD patients, derived from a llama …
domain antibody developed for oral administration in IBD patients, derived from a llama …
Infectious complications of rheumatoid arthritis and psoriatic arthritis during targeted and biological therapies: a viewpoint in 2020
O Lortholary, M Fernandez-Ruiz, JW Baddley… - Annals of the …, 2020 - ard.bmj.com
Biological therapies have improved the outcomes of several major inflammatory,
autoimmune and also neoplastic disorders. Those directed towards cytokines or other …
autoimmune and also neoplastic disorders. Those directed towards cytokines or other …
Human neutrophil elastase proteolytic activity in ulcerative colitis favors the loss of function of therapeutic monoclonal antibodies
R Curciarello, T Sobande, S Jones… - Journal of …, 2020 - Taylor & Francis
Purpose Proteases play an essential role in the pathophysiology of inflammatory bowel
disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the …
disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the …
[HTML][HTML] Alterations and potential applications of gut microbiota in biological therapy for inflammatory bowel diseases
D Pu, Z Zhang, B Feng - Frontiers in Pharmacology, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a
chronic immune-mediated inflammatory disorder of the gastrointestinal tract that is closely …
chronic immune-mediated inflammatory disorder of the gastrointestinal tract that is closely …
[HTML][HTML] C-reactive protein as a possible marker for severity and mortality of COVID-19 infection
N Tahery, M Khodadost, SJ Sherafat… - … and hepatology from …, 2021 - ncbi.nlm.nih.gov
Aim: The present study aimed to introduce a possible biomarker to differentiate between
severe and fatal conditions of COVID-19. Background: The COVID-19 pandemic, appearing …
severe and fatal conditions of COVID-19. Background: The COVID-19 pandemic, appearing …
Noncanonical NF-κB signaling upregulation in inflammatory bowel disease patients is associated with loss of response to anti-TNF agents
Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab
and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel …
and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel …
The many faces of tumor necrosis factor signaling in the intestinal epithelium
ME Delgado, T Brunner - Genes & Immunity, 2019 - nature.com
The intestinal epithelium represents an exquisite complex combination of specialized
cellular components, structural organization, as well as fine-tuned maintenance and renewal …
cellular components, structural organization, as well as fine-tuned maintenance and renewal …