[HTML][HTML] The food contaminants nivalenol and deoxynivalenol induce inflammation in intestinal epithelial cells by regulating reactive oxygen species release
S Adesso, G Autore, A Quaroni, A Popolo, L Severino… - Nutrients, 2017 - mdpi.com
Fusarium mycotoxins are fungal metabolites whose ability to affect cereal grains as multi-
contaminants is progressively increasing. The trichothecene mycotoxins nivalenol (NIV) and …
contaminants is progressively increasing. The trichothecene mycotoxins nivalenol (NIV) and …
[HTML][HTML] Polyphenolic maqui extract as a potential nutraceutical to treat TNBS-induced Crohn's disease by the regulation of antioxidant and anti-inflammatory …
T Ortiz, F Argüelles-Arias, M Illanes, JM García-Montes… - Nutrients, 2020 - mdpi.com
Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which
have been highlighted for their remarkable health benefits. Specially, maqui berries have …
have been highlighted for their remarkable health benefits. Specially, maqui berries have …
[HTML][HTML] The role of cytokines in the fibrotic responses in Crohn's disease
Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of
environmental and genetic factors in susceptible individuals. It is characterized by chronic …
environmental and genetic factors in susceptible individuals. It is characterized by chronic …
Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS)
C Zhang, H Zhu, H Jie, H Ding, H Sun - Bioengineered, 2021 - Taylor & Francis
Accumulating evidence has revealed the anti-inflammatory effects of arbutin against various
diseases. However, the effects of arbutin are not clarified in ulcerative colitis. This study was …
diseases. However, the effects of arbutin are not clarified in ulcerative colitis. This study was …
[HTML][HTML] Tumor necrosis factor inhibitors exacerbate Whipple's disease by reprogramming macrophage and inducing apoptosis
Tropheryma whipplei is the agent of Whipple's disease, a rare systemic disease
characterized by macrophage infiltration of the intestinal mucosa. The disease first manifests …
characterized by macrophage infiltration of the intestinal mucosa. The disease first manifests …
Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways …
T Zhang, GY Liu, JL Cao, YN Li, H Xue… - Drug Development …, 2022 - Wiley Online Library
Peimine (PM), a natural product extracted from Fritillaria, has anti‐inflammatory, drug
resistance reversal, and other pharmacological effects. The purpose of this study was to …
resistance reversal, and other pharmacological effects. The purpose of this study was to …
Soluble ligands as drug targets for treatment of inflammatory bowel disease
X Tong, Y Zheng, Y Li, Y Xiong, D Chen - Pharmacology & Therapeutics, 2021 - Elsevier
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is
characterized by persistent inflammation in a hereditarily susceptible host. In addition to …
characterized by persistent inflammation in a hereditarily susceptible host. In addition to …
[HTML][HTML] Oral anti-tumour necrosis factor domain antibody V565 provides high intestinal concentrations, and reduces markers of inflammation in ulcerative colitis …
S Nurbhai, KJ Roberts, TM Carlton, L Maggiore… - Scientific reports, 2019 - nature.com
V565 is an engineered TNFα-neutralising single domain antibody formulated into enteric
coated mini-tablets to enable release in the intestine after oral administration as a possible …
coated mini-tablets to enable release in the intestine after oral administration as a possible …
Loss of RHBDF2 results in an early-onset spontaneous murine colitis
Inflammatory bowel disease (IBD) is a heterogeneous group of inflammation-mediated
pathologies that include Crohn's disease and ulcerative colitis and primarily affects the colon …
pathologies that include Crohn's disease and ulcerative colitis and primarily affects the colon …
Pharmacogenetics of treatments for inflammatory bowel disease
M Lucafò, R Franca, D Selvestrel, D Curci… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Inflammatory bowel disease is a chronic inflammation of the gut whose
pathogenesis is still unclear. Although no curative therapy is currently available, a number of …
pathogenesis is still unclear. Although no curative therapy is currently available, a number of …