[HTML][HTML] Down-regulation of colonic ACE2 expression in patients with inflammatory bowel disease responding to anti-TNF therapy: implications for COVID-19

XZ Li, Y Qiu, L Jeffery, F Liu, R Feng, JS He… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Angiotensin-converting enzyme II (ACE2) is the key molecule for
understanding the pathophysiology of COVID-19. The risk of COVID-19 and impact of …

Identification of lncRNA DLEU2 as a potential diagnostic biomarker and anti-inflammatory target for ulcerative colitis

Q Lin, D Zhang, J Zhang, W Luo, Z Xu, J Yao… - Frontiers in …, 2022 - frontiersin.org
The incidence of ulcerative colitis (UC) in China has significantly increased over the past 10
years. Here we aim to explore potential diagnostic biomarkers and anti-inflammatory targets …

Application of nSMOL coupled with LC‐MS bioanalysis for monitoring the Fc‐fusion biopharmaceuticals Etanercept and Abatacept in human serum

N Iwamoto, K Yokoyama, M Takanashi… - Pharmacology …, 2018 - Wiley Online Library
The principle of nano‐surface and molecular‐orientation limited (nSMOL) proteolysis has a
unique characteristic Fab‐selective proteolysis for antibody bioanalysis that is independent …

RNA methylation in inflammatory bowel disease

Y Ozato, T Hara, S Meng, H Sato, S Tatekawa… - Cancer …, 2024 - Wiley Online Library
RNA modifications, including the renowned m6A, have recently garnered significant
attention. This chemical alteration, present in mRNA, exerts a profound influence on protein …

[HTML][HTML] Готовы ли врачи первичного звена соблюдать протоколы диагностики и лечения заболеваний, ассоциированных с Helicobacter pylori: результаты …

ДС Бордин, ТС Кролевец… - Альманах клинической …, 2021 - cyberleninka.ru
Цель-оценка комплаентности врачей первичного звена в отношении выполнения
рекомендаций по диагностике и лечению Helicobacter pylori-ассоциированных …

MIF Variant rs755622 is associated with severe crohn's disease and better response to anti-TNF Adalimumab therapy

G Jezernik, M Gorenjak, U Potočnik - Genes, 2023 - mdpi.com
Crohn's disease (CD), rheumatoid arthritis, psoriatic arthritis and other inflammatory
diseases comprise a group of chronic diseases with immune-mediated pathogenesis which …

How similar is biosimilar? A comparison of infliximab therapeutics in regard to charge variant profile and antigen binding affinity

B Beyer, N Walch, A Jungbauer… - Biotechnology …, 2019 - Wiley Online Library
Biosimilars are increasing in economic importance. Just how similar a biosimilar needs to be
to gain market approval is currently still decided on a per case basis. The authors try to shed …

IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑and p38 …

M Ohta, N Chosa, S Kyakumoto… - International …, 2018 - spandidos-publications.com
Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the
trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal …

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane

H Schneider, E Berger, B Dolan… - Biochemical …, 2019 - portlandpress.com
Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush
border membrane of small intestinal enterocytes and presents an extended O-glycosylated …

De-escalation of anti-tumor necrosis factor alpha agents and reduction in adverse effects: a systematic review

M Bouhuys, WS Lexmond, PF van Rheenen - Biomedicines, 2022 - mdpi.com
Background: The long-term use of anti-TNF-α agents can lead to adverse effects, such as
infections and immune-mediated cutaneous reactions. Whether de-escalation by dose …