The ubiquitin family member Sumo has important functions in many cellular processes
including DNA repair, transcription and cell division. Numerous studies have shown that …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …

SUMO conjugation to proteins is involved in the regulation of diverse cellular functions. We
have identified a protein, RWD-containing sumoylation enhancer (RSUME), that enhances …

Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as
a central regulatory mechanism of protein function. However, little is known about the …

Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the
regulation of lytic and latent viral infection. Like the related proteins expressed by other …

During infection, pathogenic bacteria manipulate the host cell in various ways to allow their
own replication, propagation and escape from host immune responses. Post-translational …

Post-translational modification by members of the small ubiquitin-like modifier (SUMO)
family of proteins is important for the regulation of many cellular proteins and pathways. As …

Intrinsic antiviral resistance represents the first line of intracellular defence against virus
infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the …

Posttranslational modifications are increasingly recognized as key strategies used by
bacterial and viral pathogens to modulate host factors critical for infection. A number of …

Posttranslational modification by ubiquitin and SUMO is recognized as an effective means of
controlling the stability, localization or activity of intracellular proteins, thereby contributing to …