Sumoylation is a post-translational modification by which small ubiquitin-like modifiers
(SUMO) are covalently conjugated to target proteins. This reversible pathway provides a …

Post-translational modification of proteins is a widespread mechanism used by both
prokaryotic and eukaryotic cells to modify the activity of key factors that plays fundamental …

Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a
vast variety of proteins in order to modulate their function. Sumoylation has emerged as an …

Covalent attachment of the small ubiquitin-like modifier (SUMO) to proteins constitutes a
posttranslational modification intensely studied during the last decade. From the many …

The ubiquitin proteasome system (UPS) plays a role in the regulation of most cellular
pathways, and its deregulation has been implicated in a wide range of human pathologies …

Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have
emerged as key regulators of protein function and fate. While the past few years have seen …

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs)
was discovered over a decade ago, a huge number of cellular proteins have been found to …

Voltage-gated Kv2. 1 potassium channels are important in the brain for determining activity-
dependent excitability. Small ubiquitin-like modifier proteins (SUMOs) regulate function …

The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5
(Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing …

The mouse p19Arf protein has both p53-dependent and p53-independent tumor-
suppressive activities. Arf triggers sumoylation of many cellular proteins, including Mdm2 …