Several posttranslational modifications including phosphorylation have been detected on
the glucocorticoid receptor (GR). However, the interdependence and combinatorial …

ABSTRACT Nonstructural protein 1 (NS1) is one of the major factors resulting in the efficient
infection rate and high level of virulence of influenza A virus. Although consisting of only …

Oncogenic transformation by adenovirus E1A and E1B-55K requires E1B-55K inhibition of
p53 activity to prevent E1A-induced apoptosis. During viral infection, E1B-55K and E4orf6 …

The crucial function of the PTEN tumor suppressor in multiple cellular processes suggests
that its activity must be tightly controlled. Both, membrane association and a variety of post …

Specification of retinal rod photoreceptors is determined by several different transcription
factors that activate expression of rod-specific genes and repress expression of cone …

UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of
essential cellular functions and, as such, is frequently altered in cancers. Along these lines …

Summary Ubiquitin-like (Ubl) post-translational modifications are potential targets for
therapeutics. However, the only known mechanism for inhibiting a Ubl-activating enzyme is …

cAMP is required for differentiation of human endometrial stromal cells (HESCs) into
decidual cells in response to progesterone, although the underlying mechanism is not well …

The aggressive phenotype of RA synovial fibroblasts (RASF) is characterised by the
increased expression of matrix metalloproteinase (MMP)-1 as well as the small ubiquitin like …

Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …