SUMO modification regulates the activity of numerous transcription factors that have a direct
role in cell-cycle progression, apoptosis, cellular proliferation, and development, but its role …

Posttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a
potent regulator of various cellular events. Hundreds of substrates have been identified …

Sumoylation involves the enzymatic conjugation of small ubiquitin-like modifier (SUMO)
protein to their substrate proteins. Sumoylation is not only crucial for maintaining normal …

The p53 tumour suppressor has a key role in the control of cell growth and differentiation,
and in the maintenance of genome integrity,. p53 is kept labile under normal conditions, but …

Shigella flexneri, the etiological agent of bacillary dysentery, invades the human colonic
epithelium and causes its massive inflammatory destruction. Little is known about the post …

SUMO (small ubiquitin-related modifier)-specific proteases catalyse the maturation and de-
conjugation processes of the sumoylation pathway and modulate various cellular responses …

Small ubiquitin-like modifier (SUMO) ylation is a key post-translational modification
mechanism that controls the function of a plethora of proteins and biological processes …

Phosducin regulates Gβγ-stimulated signaling by binding to Gβγ subunits of heterotrimeric G-
proteins. Control of phosducin activity by phosphorylation is well established. However, little …

Enterovirus 71 (EV71), a member of the Picornaviridae family, may cause serious clinical
manifestations associated with the central nervous system. Enterovirus 3C protease is …

Selective expression of retinal cone opsin genes is essential for color vision, but the
mechanism mediating this process is poorly understood. Both vertebrate rod and medium …