[HTML][HTML] Nitric oxide destabilizes Pias3 and regulates sumoylation
Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for
posttranslational regulation of protein function. However, it is largely unknown how the …
posttranslational regulation of protein function. However, it is largely unknown how the …
Sumoylation and ubiquitylation crosstalk in the control of ΔNp63α protein stability
ΔNp63α is finely and strictly regulated during embryogenesis and differentiation. ΔNp63α is
the only p63 isoform degraded by the proteasome after Ubiquitin and SUMO (Small …
the only p63 isoform degraded by the proteasome after Ubiquitin and SUMO (Small …
A role for paralog-specific sumoylation in histone deacetylase 1 stability
Abstract Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a
highly conserved family of deacetylases. Increased HDAC1 activity and expression often …
highly conserved family of deacetylases. Increased HDAC1 activity and expression often …
[HTML][HTML] SUMO-interacting motifs of human TRIM5α are important for antiviral activity
G Arriagada, LN Muntean, SP Goff - PLoS pathogens, 2011 - journals.plos.org
Human TRIM5α potently restricts particular strains of murine leukemia viruses (the so-called
N-tropic strains) but not others (the B-or NB-tropic strains) during early stages of infection …
N-tropic strains) but not others (the B-or NB-tropic strains) during early stages of infection …
Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes
SR da Silva, SL Paiva, JL Lukkarila… - Journal of medicinal …, 2013 - ACS Publications
The labeling of proteins with small ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers regulates
a plethora of activities within the cell, such as protein recycling, cell cycle modifications, and …
a plethora of activities within the cell, such as protein recycling, cell cycle modifications, and …
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo
WO Miles, E Jaffray, SG Campbell… - Genes & …, 2008 - genesdev.cshlp.org
Morphogens are secreted signaling molecules that form concentration gradients and control
cell fate in developing tissues. During development, it is essential that morphogen range is …
cell fate in developing tissues. During development, it is essential that morphogen range is …
BC-box protein domain-related mechanism for VHL protein degradation
ME Pozzebon, A Varadaraj… - Proceedings of the …, 2013 - National Acad Sciences
The tumor suppressor VHL (von Hippel–Lindau) protein is a substrate receptor for Ubiquitin
Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the …
Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the …
[HTML][HTML] The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious …
J Li, S Callegari, MG Masucci - PLoS pathogens, 2017 - journals.plos.org
Post-translational modification by the Small Ubiquitin-like Modifier (SUMO) regulates a
variety of cellular functions, and is hijacked by viruses to remodel the host cell during latent …
variety of cellular functions, and is hijacked by viruses to remodel the host cell during latent …
HPV E6 proteins target Ubc9, the SUMO conjugating enzyme
PR Heaton, AF Deyrieux, XL Bian, VG Wilson - Virus research, 2011 - Elsevier
The human papillomavirus oncogenic protein, E6, interacts with a number of cellular
proteins, and for some targets, E6 directs their degradation through the ubiquitin …
proteins, and for some targets, E6 directs their degradation through the ubiquitin …
[HTML][HTML] Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during …
ET Kim, YE Kim, YJ Kim, MK Lee, GS Hayward… - PLoS …, 2014 - journals.plos.org
Post-translational modification of proteins by members of the small ubiquitin-like modifier
(SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and …
(SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and …