A large number of proteins are modified post-translationally by the ubiquitin-like protein
(Ubl) SUMO. This process, known as sumoylation, regulates the function, localisation and …

Small ubiquitin-related modifier (SUMO) proteins are~ 11 kDa proteins that can be
covalently conjugated to lysine residues in defined target proteins. The resultant post …

Background SUMOylation, as part of the epigenetic regulation of transcription, has been
intensively studied in lower eukaryotes that contain only a single SUMO protein; however …

The miR-34 family of microRNAs suppresses the expression of proteins involved in
pluripotency and oncogenesis. miR-34 expression is frequently reduced in cancers; …

Integrated retroviral DNA is subject to epigenetic gene silencing, resulting in loss of
expression of viral genes as well as reporter or therapeutic genes transduced by retroviral …

ABSTRACT Adenovirus E4-ORF3 and E1B-55K converge in subverting critical overlapping
cellular pathways to facilitate virus replication. Here, we show that E1B-55K and E4-ORF3 …

Geminiviruses are DNA viruses that replicate in nuclei of infected plant cells using the plant
DNA replication machinery, including PCNA (proliferating cellular nuclear antigen), a …

SUMOylation is a reversible posttranslational modification involved in the regulation of
diverse biological processes. Growing evidence suggests that virus infection can interfere …

Background To successfully invade new hosts, plant viruses must break host resistance and
be competent to move within and between plant cells. As a means, viral proteins known as …

In the absence of ligands the corepressor N-CoR mediates transcriptional repression by
some nuclear hormone receptors. Several protein–protein interactions of N-CoR are known …