Pertussis is a highly communicable acute respiratory infection caused by Bordetella
pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks …

Traditional vaccine development against infectious diseases has been guided by the
overarching aim to generate efficacious vaccines normally indicated by an antibody and/or …

Adjuvanted nanocarrier-based vaccines hold substantial potential for applications in novel
early-life immunization strategies. Here, via mouse and human age-specific in vitro …

Background Vaccination against pertussis and seasonal influenza is recommended for all
pregnant women in the UK. More recently COVID-19 vaccination has also been offered to …

Immunization with current acellular pertussis (aP) vaccines protects against severe
pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent …

The increased susceptibility of neonates to specific pathogens has previously been
attributed to an underdeveloped immune system. More recent data suggest neonates have …

Acute respiratory infections (ARIs) are extremely common in children, especially those under
5 years old. They can lead to complications, super-infection, respiratory failure, and even …

Continuous outbreaks of pertussis around the world suggest inadequate immune protection
in infants and weakened immune responses induced over time by the acellular pertussis …

Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis, a Gram-
negative bacterium described over a century ago. Despite broad vaccine coverage and …

Pertussis cases have been reported most frequently in developed countries, but they are
predicted to be the most prevalent in developing countries. Indonesia, a developing country …