Rheumatoid arthritis (RA) causes a huge medical burden due to its high morbidity and
disability rate. Emerging evidences demonstrate that RA has a tumor-like microenvironment …

Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged
and old bone to maintain bone quality. Tight coordination of bone resorption and bone …

Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA);
however, the mechanism by which DNA damage drives OA is unclear. Previous research …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

The key to regenerative medicine is in situ regeneration of lesion cells, so as to achieve
lesion repair and regeneration. However, the complex environment of the joint cavity where …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Background Strontium ranelate is currently used for osteoporosis. The international, double-
blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl …

Within the past years, more and more attention has been devoted to the epigenetic
dysregulation that provides an additional window for understanding the possible …

As the main load-bearing structure in the human body, bone and cartilage are susceptible to
damage in sports and other activities. The repair and regeneration of bone and articular …

Osteoarthritis (OA) is the most common arthritis with a rapidly increasing prevalence.
Disease progression is irreversible, and there is no curative therapy available. During OA …