Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
[HTML][HTML] Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
[HTML][HTML] NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of
the cellular antioxidant response, controlling the expression of genes that counteract …
the cellular antioxidant response, controlling the expression of genes that counteract …
[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease
C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse …
Well-established studies have shown an elevated level of reactive oxygen species (ROS)
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …
[HTML][HTML] Oxidative stress, amyloid-β peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease
DA Butterfield, D Boyd-Kimball - Journal of Alzheimer's …, 2018 - content.iospress.com
Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …
Lipid quality control and ferroptosis: from concept to mechanism
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in aging and cancer
AV Kudryavtseva, GS Krasnov, AA Dmitriev… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …
growing older, and the incidence of cancer increases with age. There is no doubt about the …
Oxidative stress, protein modification and Alzheimer disease
A Tramutola, C Lanzillotta, M Perluigi… - Brain research bulletin, 2017 - Elsevier
Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly
population with complex etiology. Many hypotheses have been proposed to explain different …
population with complex etiology. Many hypotheses have been proposed to explain different …