Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics

L Pekar, S Krah, S Zielonka - Expert Opinion on Biological Therapy, 2024 - Taylor & Francis
Cytokines [1–3] are potent immunoregulatory proteins that have proven to be of relevance
as therapeutic modalities. In this regard, cytokines have been approved for the treatment of a …

The potential and promise for clinical application of adoptive T cell therapy in cancer

Y Li, Y Zheng, T Liu, C Liao, G Shen, Z He - Journal of Translational …, 2024 - Springer
Adoptive cell therapy has revolutionized cancer treatment, especially for hematologic
malignancies. T cells are the most extensively utilized cells in adoptive cell therapy …

Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

X Lang, X Wang, M Han, Y Guo - International Journal of …, 2024 - Taylor & Francis
Until now, there has been a lack of effective strategies for cancer treatment. Immunotherapy
has high potential in treating several cancers but its efficacy is limited as a monotherapy …

Nanobodies in cytokine‑mediated immunotherapy and immunoimaging

X Zhang, J Wang, Y Tan, C Chen… - International …, 2024 - spandidos-publications.com
Cytokines are the main regulators of innate and adaptive immunity, mediating
communications between the cells of the immune system and regulating biological …

Altered serum cytokines in patients with symptomatic disk herniation and depressive symptoms

J Bielewicz, B Daniluk, P Kamieniak - Frontiers in Neuroscience, 2024 - frontiersin.org
Purpose An increasing number of studies have indicated the important role of cytokines in
the development of depressive disturbances (DD). In medically ill patients, cytokines can …

Cytokines and CNS diseases

R Balabanov - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Cytokines are signaling molecules regulating the immune system function in health and
disease (Dinarello, 2007). They represent a special class of soluble proteins that are …

[PDF][PDF] Structure of the thrombopoietin MPL receptor complex is a blueprint for biasing hematopoiesis

IS Hitchcock, WG Grey - Cell, 2023 - eprints.whiterose.ac.uk
Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC)
maintenance and megakaryocyte differentiation. Here, we report the 3.4 Aresolution …

CEP55: an immune-related predictive and prognostic molecular biomarker for multiple cancers

GS Li, W Zhang, WY Huang, RQ He, ZG Huang… - BMC Pulmonary …, 2023 - Springer
Abstract Background Centrosomal protein 55 (CEP55) plays a significant role in specific
cancers. However, comprehensive research on CEP55 is lacking in pan-cancer. Methods In …

Inflammation in the Peripheral Nervous System after Injury

D Gu, Y Xia, Z Ding, J Qian, X Gu, H Bai, M Jiang… - Biomedicines, 2024 - mdpi.com
Nerve injury is a common condition that occurs as a result of trauma, iatrogenic injury, or
long-lasting stimulation. Unlike the central nervous system (CNS), the peripheral nervous …

PEGylation of human interferon-α2b with modified amino acids increases circulation half-life and antiproliferative activity

SK Shahzadi, M Abdul Qadir, N Mahmood… - Journal of Taibah …, 2023 - Taylor & Francis
Interferon-α2b (IFN-α2b) is used as a therapeutic agent against various types of cancer. In
the current research, modified forms of human INF-α2b were produced to investigate the …