The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

JR Wu, Y Hernandez, KF Miyasaki, EJ Kwon - Advanced drug delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

Liposomes for the treatment of brain cancer—A review

R Raju, WH Abuwatfa, WG Pitt, GA Husseini - Pharmaceuticals, 2023 - mdpi.com
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes
are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate …

Applications of focused ultrasound for the treatment of glioblastoma: a new frontier

AM Hersh, M Bhimreddy, C Weber-Levine, K Jiang… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

AA Attama, PO Nnamani, OB Onokala… - Frontiers in …, 2022 - frontiersin.org
Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level
of human development. Globally, it was estimated that there were 19.3 million new cases of …

Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …

New advances in biomedical application of polymeric micelles

A Figueiras, C Domingues, I Jarak, AI Santos, A Parra… - Pharmaceutics, 2022 - mdpi.com
In the last decade, nanomedicine has arisen as an emergent area of medicine, which
studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility …