The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

Chronic inflammation and immune responses are two core element that characterize the
tumor microenvironment. A large number of immune/inflammatory cells (including tumor …

Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

Endothelial cells that line the inner walls of blood vessels are in direct contact with blood
and display remarkable heterogeneity in their response to exogenous stimuli. These ECs …

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …