Prodrug design is a widely known molecular modification strategy that aims to optimize the
physicochemical and pharmacological properties of drugs to improve their solubility and …

Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs),
therapeutic drug monitoring (TDM) can make a significant contribution to the field of …

Introduction: There are over twenty anti-seizure medications and anti-seizure devices
available commercially in the United States. The multitude of treatment options for seizures …

Eslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine
carboxamide family that is currently approved as adjunctive therapy and monotherapy for …

Brivaracetam is the latest approved antiepileptic drug in focal epilepsy and exhibits high
affinity as SV2A-ligand. More than two thousand patients have received brivaracetam within …

Introduction This multicenter, retrospective study aimed to evaluate the efficiency, retention,
safety, and tolerability of brivaracetam (BRV) in children and adolescents with focal epilepsy …

Four “third-generation” antiepileptic drugs (AEDs) were approved for adjunctive treatment of
refractory focal onset seizures during the past 10 years. Long-term efficacy and safety of the …

Organic molecules bearing acetoxy moieties are important functionalities in natural
products, drugs, and agricultural chemicals. Synthesis of such molecules via transition metal …

Background and Purpose The KCNQ2 gene encodes for the Kv7. 2 subunit of non‐
inactivating potassium channels. KCNQ2‐related diseases range from autosomal dominant …

Lacosamide (LCM) is approved for anticonvulsive treatment in focal epilepsy and exhibits its
function through the slow inactivation of voltage-gated sodium channels (VGSCs). LCM …