Liver failure and hyperammonemia is associated with oxidative stress in brain tissue,
impaired locomotor activity, cognitive deficit, permanent brain injury, coma, and death. There …

Abstract SLC4A11 is a NH 3 sensitive membrane transporter with H+ channel-like properties
that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss …

Background: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease
with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor …

Aging occurs along with multiple pathological problems in various organs. The aged brain,
especially, shows a reduction in brain mass, neuronal cell death, energy dysregulation, and …

Ammonia is a metabolite that, at high concentrations, is implicated in neurological disorders,
such as hepatic encephalopathy (HE), which is associated with acute or chronic liver failure …

In humans, more than 50 transporters are responsible for the traffic and balance of amino
acids within and between cells and tissues, and half of them have been associated with …

Hepatic encephalopathy (HE) is a serious clinical complication, which could lead to coma
and death if not appropriately managed. There is agreement on the predominant role of …

With the development of the poultry industry, ammonia, as a main contaminant in the air, is
causing increasing problems with broiler health. To date, most studies of ammonia toxicity …

Brain edema and associated increase in intracranial pressure continue to be lethal
complications of acute liver failure (ALF). Abundant evidence suggests that the edema in …

Background & Aims In cirrhosis, astrocytic swelling is believed to be the principal
mechanism of ammonia neurotoxicity leading to hepatic encephalopathy (HE). The role of …