Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

E Eskandari, CJ Eaves - Journal of Cell Biology, 2022 - rupress.org
Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Cancer cell plasticity during tumor progression, metastasis and response to therapy

A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Single‐cell RNA sequencing in cancer research

Y Zhang, D Wang, M Peng, L Tang, J Ouyang… - Journal of Experimental …, 2021 - Springer
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …

New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects

M Huang, Y Lin, C Wang, L Deng, M Chen… - Drug resistance …, 2022 - Elsevier
Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling

X Liu, H He, F Zhang, X Hu, F Bi, K Li, H Yu… - Cell death & …, 2022 - nature.com
Exploring the epigenetic regulation mechanism of colorectal cancer (CRC) from the
perspective of N6-methyladenosine (m6A) modification may provide a new target for tumor …

Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - Nature Reviews …, 2023 - nature.com
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

RNA modifications in cancer

Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

[HTML][HTML] Tumor microenvironment-adaptive nanoplatform synergistically enhances cascaded chemodynamic therapy

Y Wang, D Wang, Y Zhang, H Xu, L Shen, J Cheng… - Bioactive Materials, 2023 - Elsevier
Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as a promising
alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect …