Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

The curative effect of sorafenib in hepatocellular carcinoma (HCC) is limited and sorafenib
resistance remains a major obstacle for HCC. To overcome this obstacle, a new photoactive …

Major depressive disorder (MDD) is one of the most prevalent psychiatric illnesses
worldwide which impairs the social functioning of the afflicted patients. Astrocytes promote …

Objective Hyperuricemia is a precursor to gout and is often present in other metabolic
diseases that are promoted by microbiome dysbiosis. We undertook this study to examine …

Macrophages are mononuclear phagocytes which derive either from blood-borne
monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an
increased risk of chronic kidney disease and gout. Probiotics have the potential effect of …

Excessive inflammatory reactions caused by uric acid deposition are the key factor leading
to gout. However, clinical medications cannot simultaneously remove uric acid and eliminate …

Renal ischemia/reperfusion (I/R) injury contributes to the development of acute kidney injury
(AKI). Kidney is the second organ rich in mitochondrial content next to the heart …