In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …

Abstract Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments
(DMTs) must both limit unwanted immune responses associated with disease initiation and …

Genome-wide association studies have identified many noncoding variants associated with
common diseases and traits. We show that these variants are concentrated in regulatory …

Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …

Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells
in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is …

Objectives: We present the first study to explore safety and efficacy of the human CD20
monoclonal antibody ofatumumab in relapsing-remitting multiple sclerosis (RRMS) …

Interest in CD8+ T cells and B cells was initially inspired by observations in multiple
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …

Monoclonal Abs against CD20 reduce the number of relapses in multiple sclerosis (MS);
commonly this effect is solely attributed to depletion of B cells. Recently, however, a subset …

We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our
understanding of the disease was largely descriptive and there were no approved therapies …

Immunological hypotheses have become increasingly prominent when studying the etiology
of schizophrenia. Autoimmune diseases, and especially the number of infections requiring …