[HTML][HTML] The pathogenesis of sepsis and potential therapeutic targets
M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …
response to infection”. Although the treatment of sepsis has developed rapidly in the past …
Mechanisms and treatment of organ failure in sepsis
C Lelubre, JL Vincent - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …
[HTML][HTML] Inflammation and cell death of the innate and adaptive immune system during sepsis
C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …
or abnormal immune response to overwhelming infection. It is now widely accepted that …
Neutrophil dysregulation during sepsis: an overview and update
XF Shen, K Cao, J Jiang, WX Guan… - Journal of cellular and …, 2017 - Wiley Online Library
Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …
[HTML][HTML] Biomarkers in pneumonia—beyond procalcitonin
M Karakioulaki, D Stolz - International journal of molecular sciences, 2019 - mdpi.com
Pneumonia is the leading infectious cause of mortality worldwide and one of the most
common lower respiratory tract infections that is contributing significantly to the burden of …
common lower respiratory tract infections that is contributing significantly to the burden of …
Novel biomarkers for sepsis: A narrative review
FF Larsen, JA Petersen - European journal of internal medicine, 2017 - Elsevier
Background Sepsis is a prevalent condition among hospitalized patients that carries a high
risk of morbidity and mortality. Rapid recognition of sepsis as the cause of deterioration is …
risk of morbidity and mortality. Rapid recognition of sepsis as the cause of deterioration is …
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …
system as a result of an uncontrolled response to infection. Septic patients show …
[HTML][HTML] Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis
S Cong, T Ma, X Di, C Tian, M Zhao, K Wang - BMC infectious diseases, 2021 - Springer
Background The aim of the study was to conduct a meta-analysis to evaluate the accuracy of
neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for the diagnosis of …
neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for the diagnosis of …
Two new neutrophil subsets define a discriminating sepsis signature
A Meghraoui-Kheddar, BG Chousterman… - American Journal of …, 2022 - atsjournals.org
Rationale: Sepsis is the leading cause of death in adult ICUs. At present, sepsis diagnosis
relies on nonspecific clinical features. It could transform clinical care to have immune-cell …
relies on nonspecific clinical features. It could transform clinical care to have immune-cell …
[HTML][HTML] Current evidence and limitation of biomarkers for detecting sepsis and systemic infection
Sepsis was recently redefined as a life-threatening disease involving organ dysfunction
caused by a dysregulated host response to infection. Biomarkers play an important role in …
caused by a dysregulated host response to infection. Biomarkers play an important role in …