Cell proliferation, apoptosis, autophagy, oxidative stress and metabolic dysregulation are
the basis of many diseases. Forkhead box transcription factor O1 (FOXO1) changes in …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Neural stem cell (NSC)-based therapy is a promising candidate for treating
neurodegenerative diseases and the preclinical researches call an urgent need for …

Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …

Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles
in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the …

Human ribosomes have long been thought to be uniform factories with little regulatory
function. Accumulating evidence emphasizes the heterogeneity of ribosomal protein (RP) …

The evolutionarily conserved FOXO family of transcription factors has emerged as a
significant arbiter of neural cell fate and function in mammals. From the neural stem cell …

The mammalian neocortex underlies our perception of sensory information, performance of
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …

Significance: Stem cell activation and differentiation occur along changes in cellular
metabolism. Metabolic transitions translate into changes in redox balance, cell signaling …

Globally, aging and diabetes are considered prevalent threats to human health. Chlorella
pyrenoidosa polysaccharide (CPP) is a natural active ingredient with multiple health benefits …