Background: Rheumatoid arthritis (RA) is a chronic disabling inflammatory disease that
causes synovial angiogenesis in an invasive manner and leads to joint destruction …

Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest
forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients …

Since the formation of new blood vessels is essential for tumour growth and metastatic
spread, inhibition of angiogenesis by targeting the vascular endothelial growth factor (VEGF) …

In clinical practice, we noticed that triple negative breast cancer (TNBC) patients had higher
shear-wave elasticity (SWE) stiffness than non-TNBC patients and a higher α-SMA …

Heat shock protein family A (HSP70) member 5 (HSPA5) is aberrantly expressed in various
tumors and closely associated with the progression and prognosis of cancer. Nevertheless …

Impairment of cardiac lymphatic vessels leads to cardiac lymphedema. Recent studies have
suggested that stimulation of lymphangiogenesis may reduce cardiac lymphedema …

Hypoxia (low O 2) is a ubiquitous feature of solid cancers, arising as a mismatch between
cellular O 2 supply and consumption. Hypoxia is associated to metastatic disease and …

The advantage of natural compounds is their lower number of side-effects when compared
to most synthetic substances. Therefore, over the past several decades, the interest in …

The vascular endothelium serves as a dynamic barrier that separates blood from interstitia.
Endothelial cells (ECs) respond rapidly to changes in the circulation and actively regulate …

Background & aims Numerous references made clear that Triphala is revered as a multiuse
therapeutic and perhaps even panacea historically. Nevertheless, the protective mechanism …