Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Current stem cell–based strategies for tissue regeneration involve ex vivo manipulation of
these cells to confer features of the desired progenitor population. Recently, the concept that …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

Systemic administration of antiangiogenic drugs that target components of the vascular
endothelial growth factor A (VEGF-A; VEGF) signal transduction pathway has become a …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Mesenchymal stem cells (MSCs) that overexpress secreted frizzled-related protein 2
(sFRP2) exhibit an enhanced reparative phenotype. The secretomes of sFRP2 …

Summary Type 1 diabetes (T1D) results from the progressive loss of β cells, a process
propagated by pro-inflammatory cytokine signaling that disrupts the balance between pro …