Over the last decade, mounting evidence has revealed the key roles of gut microbiota in
modulating the efficacy and toxicity of anticancer drugs, via mechanisms such as …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Simple Summary Cisplatin is successfully used for the treatment of various solid cancers.
Unfortunately, it shows no activity in colorectal cancer. The resistance phenotype of …

Resistance to clinical therapies remains a major barrier in cancer management. There is a
critical need for rapid and highly sensitive diagnostic tools that enable early prediction of …

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

The diverse repertoires of cellular mechanisms that progress certain cancer types are being
uncovered by recent research and leading to more effective treatment options. Ovarian …

Colorectal cancer is a common cancer in both men and women. Numerous studies on the
therapeutic effectiveness of nanoparticles against colorectal cancer have been reported …

Cisplatin (CDDP), carboplatin (CP), and oxaliplatin (OXP) are three platinating agents
clinically approved worldwide for use against a variety of cancers. They are canonically …

Pt-Based drugs play a very important role in current cancer treatments; yet, their cellular and
mechanistic aspects are not fully understood. NMR metabolomics provides a powerful tool to …

The properties of small molecule Pt (II) compounds that drive specific cellular responses are
of interest due to their broad clinical use as chemotherapeutics as well as to provide a better …