Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …

In 2011, we published a paper providing an overview about the bioavailability, efficacy, and
regulatory status of creatine monohydrate (CrM), as well as other “novel forms” of creatine …

Numerous health conditions affecting the musculoskeletal, cardiopulmonary, and nervous
systems can result in physical dysfunction, impaired performance, muscle weakness, and …

Reduction in oxygen levels is a key feature in the physiology of the bone marrow (BM) niche
where hematopoiesis occurs. The BM niche is a highly vascularized tissue and endothelial …

Reactive oxygen species (ROS) are strongly reactive chemical entities that include oxygen
regulated by enzymatic and non-enzymatic antioxidant defense mechanisms. ROS …

Angiopathy is a common complication of diabetes mellitus. Vascular endothelium is among
the first targets to experience blood-borne metabolic alterations, such as hyperglycemia and …

Aim: Risk factors contributes to a dysregulated metabolism and may ultimately increase the
predisposition for cardiovascular disease (CVD) development. To increase our …

Creatine (Cr) and phosphocreatine (PCr) are physiologically essential molecules for life,
given they serve as rapid and localized support of energy-and mechanical-dependent …

Eating late in the day is associated with circadian desynchrony, resulting in dysregulated
metabolism and increased cardiometabolic disease risk. However, the underlying …

Background and aims In the recent years creatine has been shown promising results in
patients with neurodegenerative diseases, myopathies and dystrophies. Cardiovascular …