[HTML][HTML] A review on the role of cyclin dependent kinases in cancers
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …
[HTML][HTML] The renaissance of cyclin dependent kinase inhibitors
T Ettl, D Schulz, RJ Bauer - Cancers, 2022 - mdpi.com
Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …
understanding of CDK inhibitors currently under development or clinically approved, with a …
[HTML][HTML] Identification of CDK2-related immune forecast model and ceRNA in lung adenocarcinoma, a pan-cancer analysis
TT Liu, R Li, C Huo, JP Li, J Yao, X Ji… - Frontiers in cell and …, 2021 - frontiersin.org
Background Tumor microenvironment (TME) plays important roles in different cancers. Our
study aimed to identify molecules with significant prognostic values and construct a relevant …
study aimed to identify molecules with significant prognostic values and construct a relevant …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
Based on the structural study of previously known CDK2 inhibitors, a new series of pyrazolo
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells
Serine/threonine kinases called cyclin-dependent kinases (CDKs) interact with cyclins and
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
Phthalazone tethered 1, 2, 3-triazole conjugates: In silico molecular docking studies, synthesis, in vitro antiproliferative, and kinase inhibitory activities
Abstract New phthalazone tethered 1, 2, 3-triazole derivatives 12–21 were synthesized
utilizing the Cu (I)-catalyzed click reactions of alkyne-functionalized phthalazone 1 with …
utilizing the Cu (I)-catalyzed click reactions of alkyne-functionalized phthalazone 1 with …
[HTML][HTML] Antiproliferative Activity, Multikinase Inhibition, Apoptosis-Inducing Effects and Molecular Docking of Novel Isatin–Purine Hybrids
The traditional single-treatment strategy for cancer is frequently unsuccessful due to the
complexity of cellular signaling. However, suppression of multiple targets is vital to defeat …
complexity of cellular signaling. However, suppression of multiple targets is vital to defeat …
[HTML][HTML] Design, synthesis, antitumor evaluation, and molecular docking of novel pyrrolo [2, 3-d] pyrimidine as multi-kinase inhibitors
In the last twenty years, protein kinases have been identified as important targets for cancer
therapy. In order to prevent unexpected toxicity, medicinal chemists have always focused on …
therapy. In order to prevent unexpected toxicity, medicinal chemists have always focused on …
Development of certain aminoquinazoline scaffolds as potential multitarget anticancer agents with apoptotic and anti-proliferative effects: Design, synthesis and …
Abstract Newly designed 4-aminoquinazoline derivatives (5a-f, 6a, b, 7, 8, 9, 10a-c, 11a, b,
12a, b and 13a, b) have been synthesized and evaluated for their potential multitarget …
12a, b and 13a, b) have been synthesized and evaluated for their potential multitarget …
The anti-breast cancer activity of indeno [1, 2-b] pyridin-5-one and their hydrazonal precursors endowed with anti-CDK-2 enzyme activity
A new series of aza-indeno [1, 2-b] pyridin-5-one derivatives 6a-h was designed. The novel
pyridin-5-one derivatives were constructed via cyclization of their corresponding hydrazonal …
pyridin-5-one derivatives were constructed via cyclization of their corresponding hydrazonal …