No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

Machine learning (ML) and artificial intelligence have accelerated scientific discovery,
augmented clinical practice, and deepened fundamental understanding of many biological …

Cells that were previously described as homogeneous are composed of subsets with distinct
transcriptional states. However, it remains unclear whether this cell heterogeneity influences …

Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates
optimization and maintenance of activated effector T cells (Teff). We prospectively collected …

Background Novel immunotherapy combination therapies have improved outcomes for
patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of …

Cell-cell communication (CCC) is critical for determining cell fates and functions in
multicellular organisms. With the advent of single-cell RNA-sequencing (scRNA-seq) and …

Cellular senescence is a state of permanent growth arrest that plays an important role in
wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells'(SnCs) …

Understanding the biocompatibility of biomaterials is a prerequisite for the prediction of its
clinical application, and the present assessments mainly rely on in vitro cell culture and in …

Mucosal‐associated invariant T (MAIT) cells have a semi‐invariant T‐cell receptor that
allows recognition of antigen in the context of the MHC class I‐related (MR1) protein …

The enthesis, a fibrocartilaginous transition between tendon and bone, is necessary for force
transfer from muscle to bone to produce joint motion. The enthesis is prone to injury due to …