Chromatin accessibility and the regulatory epigenome
SL Klemm, Z Shipony, WJ Greenleaf - Nature Reviews Genetics, 2019 - nature.com
Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …
role in establishing and maintaining cellular identity. The organization of accessible …
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states
Metazoan genomes are spatially organized at multiple scales, from packaging of DNA
around individual nucleosomes to segregation of whole chromosomes into distinct …
around individual nucleosomes to segregation of whole chromosomes into distinct …
[HTML][HTML] 3D chromosome regulatory landscape of human pluripotent cells
In this study, we describe the 3D chromosome regulatory landscape of human naive and
primed embryonic stem cells. To devise this map, we identified transcriptional enhancers …
primed embryonic stem cells. To devise this map, we identified transcriptional enhancers …
Loop stacking organizes genome folding from TADs to chromosomes
Although population-level analyses revealed significant roles for CTCF and cohesin in
mammalian genome organization, their contributions at the single-cell level remain …
mammalian genome organization, their contributions at the single-cell level remain …
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks
DC Di Giammartino, A Kloetgen, A Polyzos, Y Liu… - Nature cell …, 2019 - nature.com
Cell fate transitions are accompanied by global transcriptional, epigenetic and topological
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …
changes driven by transcription factors, as is exemplified by reprogramming somatic cells to …
Boundary stacking interactions enable cross-TAD enhancer–promoter communication during limb development
TC Hung, DM Kingsley, AN Boettiger - Nature Genetics, 2024 - nature.com
Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …
associating domain (TAD), some developmentally important genes have their promoter and …
[HTML][HTML] Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III
Y Jiang, J Huang, K Lun, B Li, H Zheng, Y Li, R Zhou… - Genome biology, 2020 - Springer
Background The relationship between transcription and the 3D chromatin structure is
debated. Multiple studies have shown that transcription affects global Cohesin binding and …
debated. Multiple studies have shown that transcription affects global Cohesin binding and …
[图书][B] Impressionable biologies: From the archaeology of plasticity to the sociology of epigenetics
M Meloni - 2019 - taylorfrancis.com
During the twentieth century, genes were considered the controlling force of life processes,
and the transfer of DNA the definitive explanation for biological heredity. Such views shaped …
and the transfer of DNA the definitive explanation for biological heredity. Such views shaped …
[HTML][HTML] HiCPlotter integrates genomic data with interaction matrices
KC Akdemir, L Chin - Genome biology, 2015 - Springer
Metazoan genomic material is folded into stable non-randomly arranged chromosomal
structures that are tightly associated with transcriptional regulation and DNA replication …
structures that are tightly associated with transcriptional regulation and DNA replication …