Chronic hepatitis B (CHB) continues to be an important public health problem worldwide,
including in the United States. An algorithm for managing CHB was developed by a panel of …

The template of hepatitis B virus transcription, the covalently closed circular DNA (ccc DNA),
plays a key role in the life cycle of the virus and permits the persistence of infection. It has …

Background & Aims Serum hepatitis B surface antigen (HBsAg) levels may predict treatment
response in chronic hepatitis B (CHB). We examined the association between changes in …

Hepatitis B surface antigen (HB sAg) levels in serum have been shown to reflect active
intrahepatic covalently closed circular DNA (ccc DNA) and to have additional value as a …

Background & Aims Patterns of serum hepatitis B surface antigen (HBsAg) decline during
nucleos (t) ide analogue (NA) therapy have not been well investigated. Methods We …

This study evaluated the predictive value of serum HBV DNA, HBV RNA, HBcrAg, HBsAg,
intrahepatic HBV DNA and cccDNA for HBeAg clearance and seroconversion during long …

AIM: To investigate the reduction in hepatitis B virus (HBV) covalently closed-circular DNA
(cccDNA) with entecavir (ETV) or lamivudine (LAM). METHODS: This analysis included …

Early declines in serum hepatitis B surface (HBsAg) levels, their optimal cutoffs, and
association with therapeutic endpoints in chronic hepatitis B (CHB) patients receiving …

Serum HBsAg levels have been quantified extensively in recent years with simple
completely automated assays in the various phases of the natural course of chronic HBV …

Background Hepatitis B e antigen (HBeAg) status is associated with clinical outcomes, and
seroconversion of HBeAg is one of the treatment goals. In this study, we determined the …