Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …

Metabolic programming is emerging as a critical mechanism to alter immune cell activation,
differentiation and function. Targeting metabolism does not completely suppress or activate …

The RNA N 6-methyladenosine (m 6 A) methylation is installed by the METTL3-METTL14
methyltransferase complex. This modification has critical regulatory roles in various …

Autophagy is a complicated cellular mechanism that maintains cellular and tissue
homeostasis and integrity via degradation of senescent, defective subcellular organelles …

Abstract Absent in melanoma 2 (AIM2) has been reported to be a component of
inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and …

Age-related deficits in the immune system have been associated with an increased
incidence of infections, autoimmune diseases, and cancer. Human B cell populations …

A contribution of epigenetic modifications to B cell tolerance has been proposed but not
directly tested. Here we report that deficiency of ten–eleven translocation (Tet) DNA …