Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

RESULTS: The main adverse effects of vancomycin are: hypotension, phlebitis,
nephrotoxicity, ototoxicity, hypersensitivity reactions, red man syndrome, neutropenia, chills …

The current vancomycin therapeutic guidelines recommend the use of only trough
concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both …

Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus
(MRSA) infections recommend targeting a vancomycin 24-h area under the concentration …

Vancomycin, a glycopeptide antimicrobial, is commonly employed for empirical and
definitive treatment of infections due to resistant gram-positive pathogens, notably methicillin …

We have evaluated the literature to review optimal dosing and monitoring of intravenous
vancomycin in adults, in response to evolving understanding of targets associated with …

There has been a welcome increase in the number of agents available for the treatment of
methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin remains an acceptable …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Despite therapeutic advances over recent decades, the mortality rate for sepsis and septic
shock is still approximately 25% worldwide. Early administration of appropriate intravenous …