Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐
renew and differentiate into other cell types forming the heterogeneous tumor bulk. Since …

Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent
years. ITH describes the cellular variation that enables tumour evolution, including tumour …

Metastasis is the major cause of cancer-associated death. Partial activation of the epithelial-
to-mesenchymal transition program (partial EMT) was considered a major driver of tumour …

Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with
pronounced epithelial and mesenchymal cancer cell populations. However, the cellular …

Abstract Rationale: Mesenchymal stem cells (MSCs) have been the focus of many studies
because of their abilities to modulate immune responses, angiogenesis, and promote tumor …

Pancreatic intraepithelial neoplasia is a pre-malignant lesion that can progress to pancreatic
ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical …

Rapidly growing cancer cells exhibit a strong dependence on iron for their survival. Thus,
iron-removing drugs, iron chelators, have potential applications in cancer treatment …

Ovarian cancer (OC) is one of the most lethal gynecologic malignancies. Due to the lack of
specific symptoms and screening methods, this disease is usually diagnosed only at an …

Malignancy is fuelled by distinct subsets of stem-like cells which persist under treatment and
provoke drug-resistant recurrence. Eradication of these cancer stem cells has therefore …

Prostate cancer (PCA), one of the most common malignant tumors in men, is the second
leading cause of cancer deaths in males worldwide. We report here that PCA models …