Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Pathogens, their toxic byproducts, and the subsequent immune reaction exert different forms
of stress and damage to the tissue of the infected host. This stress can trigger specific …

Background Sepsis is a syndrome with the disturbed host response to severe infection and
is a major health problem worldwide. As the front line of infection defense and drug …

Sepsis is the major cause of mortality across intensive care units globally, yet details of
accompanying pathological molecular events remain unclear. This knowledge gap has …

Secondary infections typically worsen outcomes of patients recovering from septic shock.
Neutrophil [polymorphonuclear leukocytes (PMNs)] migration to secondarily inoculated sites …

Objectives: Leukocytes are first responders to infection. Their activation state can reveal
information about specific host immune response and identify dysregulation in sepsis. This …

Sepsis and systemic inflammation are often accompanied by severe encephalopathy, sleep
disruption and delirium that strongly correlate with poor clinical outcomes including long …

Liver failure is a life-threatening complication of infections restricting the host's response to
infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways …

This narrative review critically examines the role of albumin in sepsis management and
compares it to its well-established application in liver cirrhosis. Albumin, a key plasma …

Background Sepsis, the most severe form of infection, involves endothelial dysfunction
which contributes to organ failure. To improve therapeutic prospects, elucidation of …