Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy

J Hartman, WH Frishman - Cardiology in review, 2014 - journals.lww.com
It has recently been appreciated that atherosclerosis is predominantly an inflammatory
process. Atherosclerosis begins with a fatty streak, which is made up almost entirely of …

Alpha‐linolenic acid: an omega‐3 fatty acid with neuroprotective properties—ready for use in the stroke clinic?

N Blondeau, RH Lipsky, M Bourourou… - BioMed research …, 2015 - Wiley Online Library
Alpha‐linolenic acid (ALA) is plant‐based essential omega‐3 polyunsaturated fatty acids
that must be obtained through the diet. This could explain in part why the severe deficiency …

Progress in inflammatory pathogenesis of atherosclerosis/动脉粥样硬化发病的炎症机制的研究进展

LIU Jun-tian - Xi'an jiao tong da xue xue bao. Yi xue ban, 2015 - search.proquest.com
摘要动脉粥样硬化是临床常见疾病是缺血性心脑血管病的主要病理基础迄今为止其发病机制
尚未完全清楚因而临床尚无有效而特异性的药物治疗大量基础和临床研究表明动脉粥样硬化是 …

Regulation of macrophage polarization and plasticity by complex activation signals

TD Smith, MJ Tse, EL Read, WF Liu - Integrative biology, 2016 - academic.oup.com
Macrophages are versatile cells of the immune system that play an important role in both
advancing and resolving inflammation. Macrophage activation has been described as a …

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

FM van der Valk, DF van Wijk, ME Lobatto… - … , biology and medicine, 2015 - Elsevier
Drug delivery to atherosclerotic plaques via liposomal nanoparticles may improve
therapeutic agents' risk–benefit ratios. Our paper details the first clinical studies of a …

Association of the systemic immune-inflammation index with all-cause mortality in patients with arteriosclerotic cardiovascular disease

L He, X Xie, J Xue, H Xie, Y Zhang - Frontiers in cardiovascular …, 2022 - frontiersin.org
Objective Systemic immune-inflammation index (SII), derived from blood cell counts of
circulating platelets, neutrophils, and lymphocytes, has been identified as a novel …

Knockdown of GAS5 inhibits atherosclerosis progression via reducing EZH2-mediated ABCA1 transcription in ApoE−/− mice

XD Meng, HH Yao, LM Wang, M Yu, S Shi… - … Therapy-Nucleic Acids, 2020 - cell.com
Atherosclerosis is a disorder occurring in the large arteries and the primary cause of heart
diseases. Accumulating evidence has implicated long non-coding RNAs (lncRNAs) in …

Thresholds for Arterial Wall Inflammation Quantified by 18F-FDG PET Imaging: Implications for Vascular Interventional Studies

FM van der Valk, SL Verweij, KAH Zwinderman… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: This study assessed 5 frequently applied arterial 18fluorodeoxyglucose (18F-
FDG) uptake metrics in healthy control subjects, those with risk factors and patients with …

Atherosclerosis, dyslipidemia, and inflammation: the significant role of polyunsaturated fatty acids

M Dessì, A Noce, P Bertucci… - International …, 2013 - Wiley Online Library
Phospholipids play an essential role in cell membrane structure and function. The length
and number of double bonds of fatty acids in membrane phospholipids are main …

Association of interleukin-6 with the progression of carotid atherosclerosis: a 9-year follow-up study

S Okazaki, M Sakaguchi, K Miwa, S Furukado… - Stroke, 2014 - Am Heart Assoc
Background and Purpose—Limited information is available on the long-term effects of
interleukin-6 (IL-6) on systemic atherosclerosis. The purpose of the present study was to …