Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Disruption of autophagy plays an import role in neurodegenerative disorders, where
deficient elimination of abnormal and toxic protein aggregates promotes cellular stress …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Cerebral ischemia-reperfusion (IR) is a complex pathological process. Although autophagy
can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its …

Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue
that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic …

Mounting attention has been focused on defects in macroautophagy/autophagy and the
autophagy-lysosomal pathway (ALP) in cerebral ischemia. TFEB (transcription factor EB) …

Mutations in superoxide dismutase-1 (SOD1) cause familial amyotrophic lateral sclerosis
(fALS). Recent evidence implicates adaptive responses to endoplasmic reticulum (ER) …

Stroke is one of the leading causes of death worldwide. A strong inflammatory response
characterized by activation and release of cytokines, chemokines, adhesion molecules, and …

Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key
role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed …