Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Proper myelination of axons is crucial for normal sensory, motor, and cognitive function.
Abnormal myelination is seen in brain disorders such as major depressive disorder (MDD) …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures regulating
developmental plasticity and protecting neurons against oxidative stress. PNN abnormalities …

There is growing evidence that metabolic stressors increase an organism's risk of
depression. Chronic mild stress is a popular animal model of depression and several …

Accumulating evidence suggests a role of the ephrin receptor EphA4 and the downstream
protein ephexin1 in synaptic plasticity, which is implicated in depression. We examined …

In recent years, more attention has been paid to the role of the glutamate transporter 1 (GLT-
1, EAAT2) in major depressive disorder (MDD). However, experimental data on brain GLT-1 …

Patients suffering from depression-associated cognitive impairments often recover
incompletely after remission from the core symptoms of depression (lack of energy …

Purpose Major depressive disorder (MDD) is a worldwide concern and devastating
psychiatric disease. The World Health Organization claims that MDD leads to at least 11.9 …

Background: Microstructural alterations in the hippocampus may underlie stress-related
disorders and stress susceptibility. However, whether these alterations are pre-existing …